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KMID : 0371219920140010240
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Medical Bulletin of the Presbyterian Medical Center
1992 Volume.14 No. 1 p.240 ~ p.248
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Hisotopathologic Study of Post-irradiation Specimen
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이혜경
이광민/정동규/김수곤
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Abstract
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The number of post-irradiated surgical specimen appears to have risen in recent years due to the increasing utilitzation of radiotherapy for cancer patients. Radiation therapy damages cells by its effects on the deoxyribonucleic acid and the
spectrum of
injury ranges from acute self-limited lesion to irreversible chronic lesions. We reviewed 24 cases of post-irradiated specimen and though that time interval is the main factor influencing the morphologic change.
Within six weeks, the individual cytologic changes such as bizarre nuclei altered nucleus/cytoplasm ratio, amphophilic and vaculoated cytoplasm are noted.
Chronic injury resulting from progressive changes in the fibrovascular tissue of the radiated area occur in six months after the initial course of radiation and the vascular changes of intimal thickening and fibrosis, foamy histiocytes within
media,
periadventitial fibrosis and chronic inflammatory cells infiltration are present.
Although above mentioned findings are not pathognomonic, we though them quite constant and reproducible characteristics of radiation injury.(KoreanJ Pathol 1992; 26: 593~600)
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KEYWORD
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